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Pyridine → HCID 87138614、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 5,6-Dimethoxy-1-indanone | HCID 75018 | — |
| 反応物 | (4-Nitrobenzyl)hydroxylamine hydrochloride | HCID 86662371 | — |
| 反応物 | (E)-6,7-dimethoxy-N-[(4-nitrophenyl)methoxy]-3,4-dihydro-2H-naphthalen-1-imine | HCID 87138450 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Ethyl acetate hexane | HCID 21226206 | — |
| 生成物 | HCID 87138614 | HCID 87138614 | 53% |
反応手順
5,6-Dimethoxy-1-indanone (104 mg, 0.54 mmol) was subjected to reaction with (4-nitrobenzyl)hydroxylamine hydrochloride (125 mg, 0.61 mmol) in ethanol (5 mL) and pyridine (0.7 mL, 9.03 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. Subjection of the material obtained on work up to flash chromatography (3:7 v/v ethyl acetate/hexane elution) afforded a ca. 3:1 mixture of the E- and Z-isomeric forms of the title compound (98 mg, 53%) as a pale-yellow crystalline solid, m.p. 139-144° C., Rf 0.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536157B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-c9949940468a48e7a9d9394619648779 |
| 出典メモ | uspto-grants-2013_09 |