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17,17-Bis(ethylendioxy)-5-androsten-7-one → 17,17-Bis(ethylendioxy)androstan-7-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 17,17-Bis(ethylendioxy)-5-androsten-7-one | HCID 67537234 | — |
| 反応物 | 3beta-Acetoxyandrostane-7,17-dione | HCID 69011313 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 17,17-Bis(ethylendioxy)androstan-7-one | HCID 68950713 | 82% |
反応手順
17,17-Bis(ethylendioxy)androstane-7-one was prepared in 82% yield from 3,3:17,17-bis(ethylendioxy)-5-androsten-7-one by the procedure described above for the preparation of 3β-acetoxyandrostane-7,17-dione (Prepn. 29) using EtOAc instead of EtOH. The crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 6/4). 1H-NMR (300 MHz, acetone-d6, ppm from TMS: δ 3.96-3.75 (8H, m), 2.54-1.10 (20H, m), 1.13 (3H, s), 0.83 (3H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536160B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-086cbeb82dba4328b163d8b3b7317183 |
| 出典メモ | uspto-grants-2013_09 |