関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloro-5-(trifluoromethyl)pyridine | HCID 92342 | — |
| 反応物 | 3-(4-Piperidinyl)-1H-indole | HCID 702235 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-[1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-1H-indole | HCID 4998535 | — |
反応手順
3-piperidin-4-yl-1H-indole (0.5 g, 2.5 mmol) is suspended in 10 ml of DMF and is heated to 60° C. K2CO3 and 5-trifluoromethyl-2-chloropyridine (0.54 g, 3.0 mmol) are added and the reaction mixture is stirred at 95° C. for 1 hour. K2CO3 is removed by filtration and the filtrate is concentrated and purified with a silica gel flash column using heptane and ethyl acetate as the elutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08536168B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-8f6ee38d8838478296cd066b6acc8b7a |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
