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HRID 424909作成日：2026年10月23日
Methyl 3,3,3-trifluoro-2-oxopropanoate → 3-cyclopropyl-alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester
https://huagongshe.com/ja/reaction/424909
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 3,3,3-trifluoro-2-oxopropanoate | HCID 2734931 | — |
| 反応物 | 5-cyclopropyl-2-phenyl-1H-pyrazol-3-one | HCID 66022699 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-cyclopropyl-alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester | HCID 66701601 | — |
反応手順
To a chloroform solution (5 ml) of 3-cyclopropyl-1-phenyl-5-pyrazolone (100 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (178 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08106086B2 |
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| 出典データセット | uspto-grants-2012_01 |
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| ORD ID | ord-bc90968e13994b3ba137de9c5efb7ee7 |
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| 出典メモ | uspto-grants-2012_01 |
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