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Nitrogen → 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitrogen | HCID 947 | — |
| 反応物 | 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanol | HCID 131730847 | — |
| 触媒 | Manganese dioxide | HCID 14801 | — |
| 溶媒 | 2-Oxopropiononitrile | HCID 69430 | — |
| 生成物 | 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanone | HCID 131730848 | — |
反応手順
In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-[5-(tert-butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanol (1.79 g, 6.95 mmol) in AcCN (70.0 mL) was treated at rt with MnO2 (3.36 g, 34.77 mmol) and the reaction mixture was stirred for 72 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 2: tR=1.13 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536209B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-2bd598f7296c42d0b6c9205106043659 |
| 出典メモ | uspto-grants-2013_09 |