化工社化工社 化学情報印刷レポート · 研究参考用
Water → 5-Methyloctahydro-1H-4,7-methanoinden-5-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4,7-Methano-5H-inden-5-one, octahydro- | HCID 96509 | — |
| 反応物 | HCID 178418332 | HCID 178418332 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Methyloctahydro-1H-4,7-methanoinden-5-ol | HCID 13462505 | — |
反応手順
Tricyclo [5.2.1.02,6] decan-8-one (15.0 g) in tetrahydrofuran (THF, 50 ml) is slowly added into CH3MgCl (9.7 g) in THF and the reaction mixture is stirred completely. Tetrahydrofuran (THF, 100 ml) with 5% of water is added into the reaction mixture. Then 100 ml of water is added to the reaction mixture. The reaction mixture is extracted by ether. The organic extract is concentrated in vacuo to yield 8-methyl-tricyclo [5.2.1.02,6] decan-8-ol (formula (X)) as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06316159B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-b35a707df36243debca3a18a173342c1 |
| 出典メモ | uspto-grants-2001_11 |