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Hydrochloric Acid → 2-[4-(Piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-chloro-N-phenylquinazolin-4-amine | HCID 317908 | — |
| 反応物 | 4-(Piperidin-1-yl)aniline | HCID 413501 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-[4-(Piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride | HCID 22639809 | — |
反応手順
A mixture of 2-chloro-4-phenylamino-quinazoline (0.18 g) and N-(4-aminophenyl)-piperidine (0.164 g) is heated for 3 min to produce a melt which is dissolved in isopropanol (4 ml). 4 N HCl in dioxane (1 ml) is added. Recrystallization from ethanol and diethylether yields 2-[4-(piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride, Rf (A1) 0.64, FAB-MS: (M+H)+=396. m.p.: (decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06316203B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-16574e2ab08643a29117db54970d7a8c |
| 出典メモ | uspto-grants-2001_11 |