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HRID 429026作成日：2026年10月24日
2-chloro-N-phenylquinazolin-4-amine → N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride
https://huagongshe.com/ja/reaction/429026
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-chloro-N-phenylquinazolin-4-amine | HCID 317908 | — |
| 反応物 | 4-Amino-N-methylbenzenemethanesulfonamide | HCID 2778131 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Isoamyl Alcohol | HCID 31260 | — |
| 生成物 | N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride | HCID 9825278 | — |
反応手順
A solution of 2-chloro-4-phenylamino-quinazoline (0.92 g) (prepared as described in Example 1a and N-methyl-(4-aminophenyl)-methanesulfonamide (0.80 g) in 10 ml of isopentylalcohol is stirred under nitrogen at 170° C. for 15 min in a sealed vessel. The warm reaction mixture is diluted with 10 ml ethanol and the hydrochloride salt, which is crystallizing on cooling, is filtered off to yield N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride as light yellow crystals melting at 259-263° C.; Rf (A2) 0.11, FAB-MS: (M+H)+=420. Analytical data: C22H21N5O2S+HCl.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06316203B1 |
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| 出典データセット | uspto-grants-2001_11 |
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| ORD ID | ord-500a0498b86745cab095443c4c237f6d |
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| 出典メモ | uspto-grants-2001_11 |
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