化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-Methyl-1,2-oxazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethyl 3-methyl-1,2-oxazole-4-carboxylate | HCID 317668 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 3-Methyl-1,2-oxazole-4-carboxylic acid | HCID 4589692 | 93.9% |
反応手順
Ethyl 3-methyl-4-isoxazolecarboxylate (1.3 g) is stirred at room temperature overnight in 5 mL of ethanol and 10 mL of 2.5 N sodium hydroxide. Dilution with water, cooling in ice, and acidification to pH 2 with 6 N hydrochloric acid precipitates an off-white solid which is collected by vacuum filtration, washed with ethanol/water, and dried under vacuum to give 1.0 g of 3-methyl-4-isoxazolecarboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06316479B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-9955587e1bda49679ef964de91558d80 |
| 出典メモ | uspto-grants-2001_11 |