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N-bromobutanimide → 2-Bromo-5-methoxybenzyl bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 1-Bromo-4-methoxy-2-methylbenzene | HCID 117915 | — |
| 触媒 | Azobisisobutyronitrile | HCID 6547 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | 2-Bromo-5-methoxybenzyl bromide | HCID 3525951 | 64% |
反応手順
To a solution of 2-bromo-5-methoxytoluene (50 g, 0.25 mol) in dichloroethane (375 ml), N-bromosuccinimide (48.8 g, 0.275 mol) and AIBN (1.36 g) were added and the reaction was refluxed for 4 h. The cooled solution was filtered and the solvent was evaporated to give a weight of 44.8 g crude 1-Bromo-2-bromomethyl-4-methoxy-benzene (64% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06323345B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-07f7a5122f7f4d769565c3dbd6b6dab5 |
| 出典メモ | uspto-grants-2001_11 |