Stannous chloride dihydrate → 2-Amino-4-(benzyloxy)-5-methoxybenzoic acid

HRID 432013

反応式

HRID 432013 の反応式
[CH2:1]([O:8][C:9]1[C:17]([O:18][CH3:19])=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[C:11]([N+:20]([O-])=O)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.O.Cl[Sn]Cl>CO>[NH2:20][C:11]1[CH:10]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:17]([O:18][CH3:19])=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]

参加物

4

反応物 2

HCID 61436Stannous chloride dihydrateHCID 108596334-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid

生成物 1

HCID 109676752-Amino-4-(benzyloxy)-5-methoxybenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-benzyloxy-5-methoxy 2-nitrobenzoic acid (18.18 g, 60 mmol)(D. E. Thurston et al., Synthesis (1990), 81) and SnCl2.2H2O (137 g, 0.6 mol) (Showa Chemical Company, Japan) in MeOH (800 mL) was stirred at 70° C. for 5 h. The mixture was concentrated under vacuum to a thick syrup. Ethyl acetate (300 mL) was then added. The organic phase was washed with water until it turned to a clear solution, then washed with brine, and dried over MgSO4. After removal of solvent, the crude was recrystallized from ethyl acetate to obtain the title compound in the form of a yellow solid with a yield of 15.1 g (92%).

後処理

  1. concentrationThe mixture was concentrated under vacuum to a thick syrup
  2. additionEthyl acetate (300 mL) was then added
  3. washThe organic phase was washed with water until it
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. customAfter removal of solvent
  7. customthe crude was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-87f565170a074cf9858bf3687fb98661
出典データセット
uspto-grants-2003_12
特許番号
US06660856B2

関連ノート

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