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Triethylamine → Benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 生成物 | Benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate | HCID 21981786 | 81.1% |
反応手順
The same operation as in Example (227a) was performed using 4-[(tert-butoxycarbonyl)amino]piperidine (2.00 g, 9.99 mmol), benzyl chloroformate (2.14 mL, 15.0 mmol) and triethylamine (3.48 mL, 25.0 mmol), to obtain 2.71 g of the title compound as a white solid (81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536197B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-62ef6d9df10048689be273132c9cefaf |
| 出典メモ | uspto-grants-2013_09 |