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1-Butanol → Boc-N-Me-Phe-OH
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Butanol | HCID 263 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-Methylphenylalanine | HCID 6951135 | — |
| 反応物 | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Boc-N-Me-Phe-OH | HCID 7010602 | — |
反応手順
3.6 g of H-MePhe-OH are dissolved in a mixture of ter.-butanol, 25 ml of 10% aqueous KHCO3 solution and 5 ml of 4 N sodium hydroxide. 8 ml of di-tert.-butylcarbonate are added and the mixture stirred for 2 days at room temperature. The reaction mixture is diluted with ca. 100 ml of water and extracted with ether. The aqueous phase is acidified, with stirring to pH 2. The precipitated product is extracted with acetic acid, the extract washed with water and dried over Na2SO4. The liquid is evaporated and the product crystallised from ether/petroleum ether to yield Boc-MePHe-OH. M.P. 87°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04261888 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-96ee78c924034d5a92685256586e1f57 |
| 出典メモ | uspto-grants-1981_04 |