関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropyl iodide | HCID 6362 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Amino-4,5-dimethoxybenzonitrile | HCID 735967 | — |
| 触媒 | Copper | HCID 23978 | — |
| 生成物 | 2-Isopropylamino-4,5-dimethoxy-benzonitrile | HCID 60112825 | — |
反応手順
A suspension of 4.52 g (25.4 mmol) 2-amino-4,5-dimethoxy-benzonitrile, 4.38 g (31.7 mmol) potassium carbonate and 100 mg copper powder in 15 ml 2-iodo-propane is stirred at 90° C. for 5 days. Extractive work-up with ethyl acetate/water and concentration i.V. affords a dark oil, which is purified by flash chromatography (ethyl acetate/hexane). yield: 4.15 g (74%) yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08476286B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-55a58d2306c7437e944ba3e9a8eac496 |
|---|
| 出典メモ | uspto-grants-2013_07 |
|---|
