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Phenyl chloroformate → Phenyl 1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | HCID 16640696 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Phenyl 1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 59536283 | 78% |
反応手順
To a solution of 1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (100 mg, 0.36 mmol, example 9 (step 3) and DIEA (62.8 μL, 0.36 mmol) in DCM (2 mL) was added phenyl chloroformate (45.2 μL, 0.36 mmol). The resulting mixture was reacted under the same conditions as described for example 10 to give 112 mg (78% yield) of the title compound as an off-white oil. MS (ESI, positive ion) m/z: 398 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476297B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-e00b20ee53b74487b979968facf4211e |
| 出典メモ | uspto-grants-2013_07 |