化工社化工社 化学情報印刷レポート · 研究参考用
Dextroamphetamine → (S)-N-(4-chlorobenzylidene)-1-phenylpropan-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dextroamphetamine | HCID 5826 | — |
| 反応物 | 4-Chlorobenzaldehyde | HCID 7726 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | (S)-N-(4-chlorobenzylidene)-1-phenylpropan-2-amine | HCID 59536354 | — |
反応手順
To a solution of (S)-1-phenylpropan-2-amine (626 mg, 4630 μmol) in benzene (10 mL) was added 4-chlorobenzaldehyde (651 mg, 4630 μmol) and MgSO4 (1000 mg, 8308 μmol) and the suspension stirred at RT 4 h. The suspension was filtered and the solid washed with benzene (2×2 mL). The combined filtrates were concentrated to give (S)—N-(4-chlorobenzylidene)-1-phenylpropan-2-amine, which was carried on into the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476297B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-aa6d8055ec8f463aa8ec6c4bcbdabe69 |
| 出典メモ | uspto-grants-2013_07 |