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4-Amino-5-chloro-2-methoxybenzoic acid → tert-Butyl (3-{[(4-amino-5-chloro-2-methoxyphenyl)carbonyl](methyl)amino}propyl)methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-5-chloro-2-methoxybenzoic acid | HCID 81626 | — |
| 反応物 | tert-butyl N-methyl-N-(3-(methylamino)propyl)carbamate | HCID 17868293 | — |
| 生成物 | tert-Butyl (3-{[(4-amino-5-chloro-2-methoxyphenyl)carbonyl](methyl)amino}propyl)methylcarbamate | HCID 86663478 | 68.4% |
反応手順
4-Amino-5-chloro-2-methoxybenzoic acid (500 mg, 2.48 mmol) and tert-butyl methyl[3-(methylamino)propyl]carbamate (652 mg, 3.22 mmol) were used to give the title compound (655 mg; yield, 68%) as a colorless oily substance according to the method described in Example 12a.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476253B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-447434d1fa3f443f8a556975f88c5fac |
| 出典メモ | uspto-grants-2013_07 |