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4-Chloro-3-nitroquinoline → 4-{[(3-nitroquinolin-4-yl)amino]methyl}tetrahydro-2H-pyran-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-3-nitroquinoline | HCID 11275808 | — |
| 反応物 | 4-(Aminomethyl)oxan-4-ol | HCID 43608754 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-{[(3-nitroquinolin-4-yl)amino]methyl}tetrahydro-2H-pyran-4-ol | HCID 57515395 | 90% |
反応手順
4-Chloro-3-nitroquinoline (12.0 g, 57.5 mmol) and was reacted with 4-(aminomethyl)tetrahydro-2H-pyran-4-ol (11.3 g, 86.3 mmol) according to the method described in Part C of Example 9. The crude yellow solid was stirred in water (100 mL) and was isolated by filtration, dried under vacuum, and recrystallized from 1,2-dichloroethane to yield 4-{[(3-nitroquinolin-4-yl)amino]methyl}tetrahydro-2H-pyran-4-ol as bright yellow crystals (15.6 g, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541438B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-44b0f603324644258a8f588b5d525c59 |
| 出典メモ | uspto-grants-2013_09 |