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Water → [2-(3-Bromophenoxy)ethyl]dimethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 3-Bromophenol | HCID 11563 | — |
| 反応物 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [2-(3-Bromophenoxy)ethyl]dimethylamine | HCID 413371 | — |
反応手順
3-Bromophenol (0.870 g, 5.00 mmol), (2-chloro-ethyl)-dimethylamine hydrochloride (0.792 g, 5.50 mmol) and Cs2CO3 (8 g, 25 mmol) were combined in DMF (20 mL) and the mixture was heated at reflux over night. H2O (20 mL) was added and the mixture was extracted with EtOAc, then washed with 2N NaOH and brine. The organic layers were combined, dried over Na2SO and concentrated to a brown oil which was then purified by flash chromatography (eluent: 20% EtOAc in hexanes).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481733B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-7b6c563c346040629f1a39ef6f906e44 |
| 出典メモ | uspto-grants-2013_07 |