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Triethylamine → Quinoline-6-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Quinoline-6-carboxamide | HCID 11052097 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Quinoline-6-carbonitrile | HCID 592995 | 60.5% |
反応手順
To a solution of quinoline-6-carboxamide (177 g, 1.03 mol) in chloroform (1.5 lit.) and triethylamine (520.15 g, 5.15 mol), trifluoroacetic anhydride (540.34 g, 2.57 mol) was added dropwise below 10° C. After 1.5 h, the pH was adjusted to 7 with sodium bicarbonate solution and extracted with dichloromethane. The organic layer was dried with sodium sulphate and concentrated to afford the title compound as a brown solid (96 g, 59%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481739B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-5c5d4f6564be47c5ab8ebc05a21d0e28 |
| 出典メモ | uspto-grants-2013_07 |