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3-Chlorophenoxyacetyl chloride → 4-{2-[(3-Chlorophenoxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chlorophenoxyacetyl chloride | HCID 7010339 | — |
| 反応物 | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| 生成物 | 4-{2-[(3-Chlorophenoxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 59496740 | — |
反応手順
This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from (3-chlorophenoxy)acetyl chloride (Lancaster, Cat. #L18427) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=493.2/495.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481732B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-424f3f5b5f014613b31d109760266ba6 |
| 出典メモ | uspto-grants-2013_07 |