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2-(Trifluoromethyl)benzoyl chloride → 4-Methyl-2-(2-trifluoromethylbenzoylamino)thiazole-5-carboxylic Acid Benzylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Trifluoromethyl)benzoyl chloride | HCID 67561 | — |
| 反応物 | N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid | HCID 210824 | — |
| 生成物 | 4-Methyl-2-(2-trifluoromethylbenzoylamino)thiazole-5-carboxylic Acid Benzylamide | HCID 59369686 | 36% |
反応手順
Following the procedure as described in Example 2, making variations only as required to use 2-trifluoromethylbenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 36% yield; 1H NMR (CDCl3, 300 MHz) δ 7.79-7.26 (m, 10H), 5.94 (s, br, 1H), 4.59 (d, J=5.8 Hz, 2H), 2.22 (s, 3H); MS (ES+) m/z 420.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541457B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-bd3aa3a4bb114d30b164221407ed909c |
| 出典メモ | uspto-grants-2013_09 |