3-(Trifluoromethyl)benzoyl chloride → 4-Methyl-2-(3-trifluoromethylbenzoylamino)thiazole-5-carboxylic Acid Benzylamide

関与物質

反応手順

Following the procedure as described in Example 2, making variations only as required to use 3-trifluoromethylbenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 27% yield; m.p. 195-196° C.; 1H NMR (CDCl3, 300 MHz) δ 8.15 (s, 1H), 8.07 (d, J=7.8 Hz, 1H), 7.85 (d, J=7.8 Hz, 1H), 7.65 (t, J=7.8 Hz, 1H), 7.40-7.27 (m, 5H), 5.97 (t, J=4.7 Hz, 1H), 4.59 (d, J=5.5 Hz, 2H), 2.49 (s, 3H); MS (ES+) m/z 420 (M+1).

情報源と証拠