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3-Methoxytyramine → 1-Methyl-3-{N-[beta-(4-hydroxy-3-methoxyphenyl)ethyl]}carbamoylpyridinium iodide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxytyramine | HCID 1669 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 1-Methyl-3-{N-[beta-(3,4-dihydroxyphenyl)ethyl]carbamoyl}pyridinium iodide | HCID 13473421 | — |
| 生成物 | 1-Methyl-3-{N-[beta-(4-hydroxy-3-methoxyphenyl)ethyl]}carbamoylpyridinium iodide | HCID 14050425 | — |
反応手順
N-nicotinoyl-3-methoxytyramine was prepared by following the procedure used for the preparation of compound 7. The isolated crude amide was quaternized directly with methyl iodide following the method used for the preparation of compound 6a. Crystallization from methanol gave a yellow crystalline compound, m.p. 192°-194° C. with overall yield of 84%, calculated on the basis of 3-methoxytyramine starting material. NMR (D2O) closely similar to that of 6a except for the singlet at δ 3.66 for OCH3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04727079 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-637be44371d74ee394c7fcecade573e7 |
| 出典メモ | uspto-grants-1988_02 |