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Triethylamine → 2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Octoxybenzoyl hydrazine | HCID 4281533 | — |
| 反応物 | 2,5-Dibromobenzoyl chloride | HCID 13450524 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide | HCID 21982102 | 126.5% |
反応手順
Under a blanket of nitrogen, 2,5-dibromobenzoyl chloride (57.43 g, 0.11925 mol) was added to a solution of 4-octyloxybenzoic acid hydrazide (50.88 g, 0.1925 mol) and triethylamine (27 mL, 19.48 g, 0.1925 mol) in 800 mL of methylene chloride. The reaction mixture was stirred for 5 hours at room temperature. The precipitated solid was filtered off and re-crystallized from hot DMF/water gave 79.38 g (78% yield) 2,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07192657B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-3c90c261d377472f80df95c24aa86fa6 |
| 出典メモ | uspto-grants-2007_03 |