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2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide → 2-(2,5-Dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide | HCID 21982102 | — |
| 溶媒 | Phosphorus oxychloride | HCID 24813 | — |
| 生成物 | 2-(2,5-Dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole | HCID 21982073 | 89% |
反応手順
A mixture of 2,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide (39.1 g, 0.0743 mol) and phosphorus oxychloride (203 mL) was refluxed for 8 hrs. Unreacted phosphorus oxychloride was distilled off and the residue poured onto crushed ice. The precipitated solid was collected by filtration and re-crystallized from EtOH/water to give 33.6 g (89% yield) 2-(2,5-dibromophenyl)-5-[4-(octyloxy)phenyl]1,3,4-oxadiazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07192657B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-155e2d177b64459fbe2de377a1f1cb55 |
| 出典メモ | uspto-grants-2007_03 |