2-Methyl-1,3-benzothiazol-5-ol → (2S)-2-Methoxy-3-{4-[3-(2-methyl-benzothiazol-5-yloxy)-propoxy]-phenyl}-propionic acid

関与物質

反応手順

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 2-methyl-5-benzothiazolol and cleavage from the resin (Standard Procedure G) to give an oily solid. 1H-NMR (200.15 MHz, CDCl3): 7.65 (d, 1 H, J=8.9), 7.36–7.35 (m, 1 H), 7.16 (d, 2 H, J=8.9), 7.03 (dd, 1 H, J=8.9, 2.4), 6.86 (dd, 2 H, J=6.5, 1.9), 4.22 (t, 2 H, J=35.9), 4.18 (t, 2 H, J=6.2), 4.01 (dd, 2 H, J=6.4, 5.4), 3.43 (s, 3 H), 3.14–2.94 (m, 2 H), 2.87 (s, 3 H), 2.27 (qn, 2 H, J=6.2) ppm.

情報源と証拠