Potassium Carbonate → HCID 178490300、化合物

関与物質

反応手順

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 3-methoxybenzylbromide (442 mg; 0.308 ml; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.143 g (38.3%); MS m/z: 374.1 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 3.68 (s, 6H); 4.64 (s, 4H); 6.69 (br s, 1H); 6.72 (dd, 1H, 4J=2.1 Hz, 3J=8.9 Hz); 6.78 (dd, 2H, 4J=2.4 Hz, 3J=7.9 Hz); 6.83-6.87 (m, 4H); 7.22 (t, 2H, 3J=7.9 Hz); 7.33 (d, 1H, 3J=8.9 Hz); 7.90 (s, 1H); 11.92 (br s, 1H); HPLC (METHOD [A]): rt 15.00 min (92.7%)

情報源と証拠