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1,1'-Carbonyldiimidazole → 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | N-Benzylaminodiacetic acid | HCID 77606 | — |
| 反応物 | 5-Aminoindole | HCID 78867 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione | HCID 22931025 | — |
反応手順
N-Benzyliminodiacetic acid was reacted with CDI and 5-aminoindole in THF to obtain 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione, which was then reacted with lithium aluminum hydride in THF. Conc. hydrochloric acid and palladium hydroxide were added to an ethanol solution of thus obtained compound and the whole was reacted under a hydrogen atmosphere of 3 atm for 65 hours to obtain an objective compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196080B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-b6dd4d4e1f0746f5a86b715e167a3784 |
| 出典メモ | uspto-grants-2007_03 |