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Sodium cyanoborohydride → (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-8-yl-ethyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 1-(Quinolin-8-yl)ethan-1-amine | HCID 12208793 | — |
| 反応物 | 6,4'-Dimethoxybiphenyl-3-carbaldehyde | HCID 22391191 | — |
| 反応物 | (6,4'-Dimethoxybiphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine | HCID 22391337 | — |
| 生成物 | (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-8-yl-ethyl)-amine | HCID 22391354 | 72% |
反応手順
The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-quinolin-8-yl-ethylamine (510 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 72% yield (287 mg, 0.72 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196102B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-3775a5953e614470b6b29c98e339b3bb |
| 出典メモ | uspto-grants-2007_03 |