関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane | HCID 20374 | — |
| 反応物 | 5-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one | HCID 14763395 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-6-methoxy-indan-1-one | HCID 18445673 | — |
反応手順
A mixture of 5-Hydroxy-6-indan-1-one, Intermediate H, (0.50 g, 0.0028 mol), 4-chloromethyl-2,2-dimethyl-1,3-dioxolane (0.766 mL, 0.0056 mol), potassium carbonate (1.54 g, 0.011 mol) and DMF (20.0 mL) was stirred at 95° C. for 3 days. Water (150.0 mL) was added and the mixture was extracted with ethyl acetate (2×150 mL). The organic layer was washed with sat. NaHCO3, brine and dried over Na2SO4. The solvent was then removed in vacuo to yield 5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-6-methoxy-indan-1-one (Intermediate I) as light brown solid. MS m/z 293 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196110B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-a7473ebca2bf4b33bce2e1449d44670e |
|---|
| 出典メモ | uspto-grants-2007_03 |
|---|
