関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Malonic Acid | HCID 867 | — |
| 反応物 | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-Thiophen-2-ylprop-2-enoic acid | HCID 92868 | — |
反応手順
A mixture of thiophene-2-carbaldehyde (Compound 66a) (1.20 g, 0.0107 mol), malonic acid (1.11 g, 0.0107 mol) and ammonium acetate (0.825 g, 0.0107 mol) in DMF (8.5 mL) was heated to 100° C. for 3 h. The system was diluted with ethyl acetate and washed with water and dried over MgSO4. The solvent was removed in vacuo and the title compound was purified by silica gel column chromatography using 3:1 Hexanes:ethyl acetate as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196110B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-dc6b503372ff491c9ba7d69950f12636 |
|---|
| 出典メモ | uspto-grants-2007_03 |
|---|
