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p-Toluenesulfonic acid → 3-Amino-1-(3-bromo-4-chlorobenzyl)-pyrazol-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | beta-Aminobeta-ethoxyacrylic acid ethyl ester | HCID 278451 | — |
| 反応物 | 3-Bromo-4-chlorobenzylhydrazine | HCID 23334355 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-Amino-1-(3-bromo-4-chlorobenzyl)-pyrazol-5-one | HCID 20367315 | — |
反応手順
49 g of β-amino-β-ethoxyacrylic acid ethyl ester and 2 g of p-toluenesulphonic acid were dissolved in 225 ml of ethanol and 72 g of 3 -bromo-4-chlorobenzylhydrazine were added under nitrogen. After standing overnight, the compound identified above had settled out as a precipitate and was filtered off and recrystallised twice from ethanol. Melting point: 171°-172° C, 40 g (43%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04061653 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-dc2f9e3c43324419b09926dd65c45197 |
| 出典メモ | uspto-grants-1977_12 |