Chloromethyl Methyl Ether → HCID 20285666、化合物

HRID 460946

反応式

HRID 460946 の反応式
[CH3:1][C:2]1[S:3][C:4]([CH3:8])=[CH:5][C:6]=1[CH3:7].CO[CH2:11][Cl:12]>C(O)(=O)C>[CH3:8][C:4]1[S:3][C:2]([CH3:1])=[C:6]([CH3:7])[C:5]=1[CH2:11][Cl:12]

参加物

4

反応物 2

HCID 7864Chloromethyl Methyl EtherHCID 745312,3,5-Trimethylthiophene

生成物 1

HCID 20285666HCID 20285666、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

24.6 G. of 2,3,5-trimethyl-thiophene, 14.8 g. of freshly distilled chloromethyl methyl ether and 52 g. of glacial acetic acid were combined in a glass pressure bottle and stirred at room temperature for 41/2 hours. The resulting reaction mixture was poured into ice water, stirred for 10 min. and extracted with benzene. The combined benzene extracts were washed twice with saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated. The resulting 2,4,5-trimethyl-3-chloromethyl-thiophene was used for the next step without any further purification.

後処理

  1. customThe resulting reaction mixture
  2. stirringstirred for 10 min.
  3. extractionextracted with benzene
  4. washThe combined benzene extracts were washed twice with saturated sodium chloride solution
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customThe resulting 2,4,5-trimethyl-3-chloromethyl-thiophene was used for the next step without any further purification

出典と根拠

ORDレコード
ord-dd0a15bced474c32bde15147eb329c83
出典データセット
uspto-grants-1977_12
特許番号
US04061656

関連ノート

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