化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → 3-(Dimethylamino)-6-hydroxymethyl-1,2,3,4-tetrahydrocarbazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 3-(Dimethylamino)-6-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole | HCID 12891786 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(Dimethylamino)-6-hydroxymethyl-1,2,3,4-tetrahydrocarbazole | HCID 12891867 | — |
反応手順
A solution of 12.8 g. of 3-(dimethylamino)-6-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole (Example 43) in 350 ml. of dry tetrahydrofuran was added dropwise to a refluxing solution of 3.5 g. of lithium aluminum hydride in 100 ml. of dry tetrahydrofuran and refluxing was continued for one hour after completion of the addition. Ethyl acetate was added followed by water, the mixture was filtered, and the filtrate was evaporated to dryness to give, after recrystallization from ethyl alcohol, 6.4 g. of 3-(dimethylamino)-6-hydroxymethyl1,2,3,4-tetrahydrocarbazole, m.p. 195°-197° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04062864 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-eed915d4159a4ac489052b6a01448978 |
| 出典メモ | uspto-grants-1977_12 |