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1,3-Diphenyl-2-propanone → 3,5-diphenyl-4H-pyran-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Diphenyl-2-propanone | HCID 7593 | — |
| 反応物 | Ethyl formate | HCID 8025 | — |
| 反応物 | Disodium | HCID 141233 | — |
| 反応物 | 3,4-Pentadien-2-one | HCID 10931367 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | 1,5-Dihydroxy-2,4-diphenyl-1,4-pentadien-3-one | HCID 70583784 | — |
| 生成物 | 3,5-diphenyl-4H-pyran-4-one | HCID 282189 | — |
反応手順
Benary and Bitter, Ber. 61, 1058 (1928) taught the synthesis of an intermediate disodium salt of 1,5-dihydroxy-2,4-diphenyl-1,4-pentadien-3-one by the condensation of 1,3-diphenyl-2-propanone with ethyl formate in the presence of sodium methoxide. The intermediate pentadienone is neutralized with strong acid to form 3,5-diphenyl-4-pyrone. Reaction of the pyrone with ammonium acetate at an elevated temperature produces 3,5-diphenyl-4(1H)-pyridinone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04065290 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-fb6b1afe2c864e338ac79da0569931d5 |
| 出典メモ | uspto-grants-1977_12 |