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Sodium Azide → 5-(2-Chloro-4-trifluoromethylphenoxy)-2-nitrophenyl azide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)- | HCID 156238 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 5-(2-Chloro-4-trifluoromethylphenoxy)-2-nitrophenyl azide | HCID 13505357 | — |
反応手順
A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)-1,2-dinitrobenzene (2.0 g, 5.5 mmol) and sodium azide (1.1 g, 16.6 mmol) in acetone (25 ml) is heated under reflux for 3.5 hours. The reaction is then cooled and filtered, and the filtrate is stripped. The residue is taken up in chloroform, washed with water (2X) and with brine, dried, stripped and purified by preparative thin layer chromatography (prep. TLC) (silica gel, eluting with 15% ethyl acetate/hexane) to give 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrophenyl azide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04544400 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-6be467e2eaa24931ab7484da4a7a0218 |
| 出典メモ | uspto-grants-1985_10 |