化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Amino-5-bromo-1,3,4-thiadiazole | HCID 3650883 | — |
| 反応物 | 4-[3-(1-Piperidinylmethyl)phenoxy]2-butene-1-amine | HCID 54432280 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine | HCID 54123024 | — |
反応手順
0.6 g (2.3 mmol) of 4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine, 0.35 ml of triethylamine and 0.42 g (2.3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amin are heated under reflux in 20 ml of THF for 3 hours. Solid triethylammonium bromide is filtered off, the filtrate is concentrated by evaporation and the oily residue is purified by preparative layer chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04727081 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-8eb4fc42e2804d748fd87ba8aac6a162 |
| 出典メモ | uspto-grants-1988_02 |