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Dimethyl Sulfoxide → 2-(Allyloxy)-4-methyl-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Allyl chloride | HCID 7850 | — |
| 反応物 | 6-Nitro-m-cresol | HCID 12788 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(Allyloxy)-4-methyl-1-nitrobenzene | HCID 13575666 | — |
反応手順
A solution of 26.1 g of sodium hydroxide in 50 ml of water was added drop-by-drop over 5 minutes to a stirred mixture of 100 g of 3-methyl-6-nitrophenol, 400 ml of dimethyl sulfoxide (DMSO) and 53.6 g of 3-chloropropene initially at room temperature. The temperature of the mixture rose to 43° C. The mixture was heated at 90°-110° C. for two hours, poured into water and filtered, to give 1-(2-propenyloxy)-3-methyl-6-nitrobenzene (1A), as a light yellow solid, m.p.: 30°-32° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04550121 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-6462610a16ae4455be5ad5cc59e613cb |
| 出典メモ | uspto-grants-1985_10 |