Ethyl 2-chloro-2-ethoxyacetate → HCID 20386798、化合物

関与物質

反応手順

Into a three-necked 250 ml flask are added 25.1 g (0.1 M) N- (2-chloro-benzyl)-2-(2-thienyl)ethylamine dissolved in 30 ml dimethylformamide. Ethyl 2-chloro-2-ethoxy-acetate (18.3 g; 0.11 M) is then added over 6 minutes, and the resulting material is heated at 80° C. for 4 hours after which the desired product begins to precipitate out. After cooling of the medium, the product is filtered off and recrystallized from 3×20 ml acetone, to give 20.5 g 5-(2-chloro-benzyl)-4-ethoxy-carbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (Yield: 55%).

情報源と証拠