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4-Bromoanisole → 4-Methoxy-4'-methylbiphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromoanisole | HCID 7730 | — |
| 反応物 | Sodium p-toluenesulfinate | HCID 2723791 | — |
| 反応物 | Calciumoxide | HCID 6850728 | — |
| 触媒 | 1,2-Bis(diphenylphosphino)ethane | HCID 74267 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-Methoxy-4'-methylbiphenyl | HCID 1704759 | 75% |
反応手順
3.56 g (20 mmol) of sodium p-toluenesulfinate, 3.74 g (20 mmol) of p-bromoanisole, 0.0225 g (0.1 mmol) of palladium acetate, 0.0478 g (0.12 mmol) of 1,2-bis(diphenylphosphino)-ethane, 6.73 g (120 mmol) of calcium oxide and 60 ml of N-methyl-2-pyrrolidone were placed in a 100 ml round bottom flask and reacted at 150° C. in a nitrogen gas stream for 6 hours. After the completion of the reaction, the reaction mixture was analyzed by means of high performance liquid chromatography. The analysis showed that 15.0 mmol (yield 75%) of 4'-methoxy-4-methylbiphenyl was formed in the reaction mixture solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05159082 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-76c8b61fc81443b8a9bc8866e402b405 |
| 出典メモ | uspto-grants-1992_10 |