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1,1'-Carbonyldiimidazole → N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid | HCID 58393097 | — |
| 反応物 | 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N-methylethanamine | HCID 67217191 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide | HCID 46175901 | — |
反応手順
The title compound was prepared according to general procedure AA using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (150 mg, 0.42 mmol), CDI (276 mg, 0.84 mmol) and 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N-methylethanamine (80 mg, 0.42 mmol) in DCE (8 mL).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-d0960cb4c28444e6a89068ce66c854d9 |
| 出典メモ | uspto-grants-2014_01 |