化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic anhydride → Pga1
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | Alprostadil | HCID 5280723 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Pga1 | HCID 5281912 | — |
反応手順
Alternately, the PGE1 -type compound is transformed to a bis-trifluoroacetate, for example by reaction with trifluoroacetic anhydride in the presence of pyridine in a solvent at 0° to 5° C., and thereafter contacted with a low-boiling alcohol (preferably b.p. below 110° C.) with a tertiary amine to form a PGA1 -type compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04175202 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-a11fac49e947493ab26228d4b32a677d |
| 出典メモ | uspto-grants-1979_11 |