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Trifluoroacetic acid → 6-Chloro-4-(2,4,6-trimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | 2,4,6-Trimethylstyrene | HCID 13036 | — |
| 反応物 | 2-Ketobutyrate | HCID 3593277 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 6-Chloro-4-(2,4,6-trimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester | HCID 10133002 | — |
反応手順
Compound 49 was prepared by the basic process from 5.0 mmol 4-chloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 2,4,6-trimethylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699877B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-d326ce09a18c49a4b5baf9d653371c92 |
| 出典メモ | uspto-grants-2004_03 |