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Trifluoroacetic acid → 7,9-dichloro-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Cyclopentene | HCID 8882 | — |
| 反応物 | 3,5-Dichloroaniline | HCID 12281 | — |
| 反応物 | 2-Ketobutyrate | HCID 3593277 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7,9-dichloro-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester | HCID 9858001 | 89% |
反応手順
Compound 59 was prepared in a yield of 89% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol cyclopentene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699877B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-01fd5605296643c9b0e9d93cb0a60418 |
| 出典メモ | uspto-grants-2004_03 |