関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetraethyltin | HCID 11704 | — |
| 反応物 | Lithium Chloride | HCID 433294 | — |
| 反応物 | 8-Bromo-2-methylquinoline-4-carboxylic Acid Ethyl Ester | HCID 69831355 | — |
| 触媒 | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-Ethyl-2-methylquinoline-4-carboxylic Acid Ethyl Ester | HCID 54492735 | 52% |
反応手順
8-Bromo-2-methylquinoline4-carboxylic acid ethyl ester (0.5 g), lithium chloride (0.216 g), tetraethyltin (0.435 g) and bis(triphenylphosphine)palladium (II) chloride (0.05 g) were combined in dimethylformamide (20 ml) and heated at 100° C. for 24 h. Solvent was removed at reduced pressure, the residue dissolved in dichloromethane and filtered. Solvent was removed at reduced pressure and the residue column chromatographed (silica gel, 5% diethyl ether/pentane) to give the title compound (0.215 g). m/z (API+): 244 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06699879B1 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-26d0a82c2dfb4cb4aa849e059193991f |
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| 出典メモ | uspto-grants-2004_03 |
|---|
