methyl (2E)-3-[2-(trifluoromethyl)-5-pyrimidinyl]-2-propenoate → Methyl 3-[2-(trifluoromethyl)-5-pyrimidinyl]propanoate

関与物質

反応手順

A mixture of methyl (2E)-3-[2-(trifluoromethyl)-5-pyrimidinyl]-2-propenoate (870 mg, 3.75 mmol) and Pd/C (39.9 mg, 0.375 mmol) in methanol (4 mL) was stirred at room temperature for 1 h under hydrogen. After cooling, the mixture was filtered through silica gel. The filtrate was concentrated to afford the title compound (577 mg, 2.47 mmol, 65.8% yield). LCMS: rt=2.47 min, [M+H+]=235

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