化工社化工社 化学情報印刷レポート · 研究参考用
CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | CID 367964 | HCID 367964 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(4-Fluorophenyl)-2-methylpropanoic acid | HCID 15487791 | — |
反応手順
To p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol is added 11.0 g of 5% Pd/C. The mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i. When hydrogen uptake ceases, the catalyst is filtered off, and the solvent is evaporated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699894B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-180a29866e24432681a27dff44e17ebd |
| 出典メモ | uspto-grants-2004_03 |