化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → 4-Methylphenyl-2-propenal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Lilac acetaldehyde | HCID 61006 | — |
| 反応物 | Dimethyl(methylene)ammounium iodide | HCID 2724133 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 4-Methylphenyl-2-propenal | HCID 18000904 | — |
反応手順
2.57 g of aldehyde 37 is introduced into 300 ml of methylene chloride under nitrogen, and 6.5 ml of triethylamine and 7.1 g of Eschenmoser's salt are added at 0° C. After 2.5 hours at 0° C., saturated ammonium chloride solution is added, extracted with methylene chloride, washed with sodium chloride solution, dried on sodium sulfate and concentrated by evaporation. The residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 1.94 g of title compound 38 accumulates as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06642218B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-d8133d68e7694eb5b0601502f575c14f |
| 出典メモ | uspto-grants-2003_11 |