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HRID 479233作成日：2026年10月24日
Sodium hydride → [Rac]-2-ethoxy-3-{7-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-benzo[b]thiophen-4-yl}-propionic acid methyl ester
https://huagongshe.com/ja/reaction/479233
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 4-Isopropoxybenzaldehyde | HCID 250077 | — |
| 反応物 | 4-(Chloromethyl)-2-(4-isopropoxyphenyl)-5-methyl-1,3-oxazole | HCID 21974254 | — |
| 反応物 | [Rac]-2-ethoxy-3-(7-hydroxy-benzo[b]thiophen-4-yl)-propionic acid methyl ester | HCID 68616696 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [Rac]-2-ethoxy-3-{7-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-benzo[b]thiophen-4-yl}-propionic acid methyl ester | HCID 69555807 | — |
反応手順
In analogy to the procedure described in example 108 c], [rac]-2-ethoxy-3-(7-hydroxy-benzo[b]thiophen-4-yl)-propionic acid methyl ester (example 151 a]) was treated with 4-chloromethyl-2-(4-isopropoxy-phenyl)-5-methyl-oxazole (prepared from 4-isopropoxy-benzaldehyde and diacetyl monoxyme followed by treatment with POCl3 in analogy to the procedures described in examples 21 a] and b]) and sodium hydride in N,N-dimethylformamide to yield [rac]-2-ethoxy-3-{7-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-benzo[b]thiophen-4-yl}-propionic acid methyl ester, which was further saponified in analogy to the procedure described in example 91 e] to yield [rac]-2-ethoxy-3-{7-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-benzo[b]thiophen-4-yl}-propionic acid as colorless solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06642389B2 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-d0e81192d44349f89f304783e18da47a |
|---|
| 出典メモ | uspto-grants-2003_11 |
|---|
